The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells

The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells

Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER+/PR+MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined drugs resulted in lower IC50 values...

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Bibliographic Details
Main Authors: Mohadeseh Hasanpourghadi, Nazia Abdul Majid, Mohd Rais Mustafa
Format: Article
Language:English
Published: PeerJ Inc. 2018-09-01
Series:PeerJ
Subjects:
Breast cancer
microRNA
Survivin
Synergism
NF-κB
Online Access:https://peerj.com/articles/5577.pdf

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