Somatostatin-IRES-Cre Mice: Between Knockout and Wild-Type?

Somatostatin-IRES-Cre Mice: Between Knockout and Wild-Type?

The neuropeptide somatostatin (SOM) is widely expressed in rodent brain and somatostatin-IRES-Cre (SOM-cre) mouse strains are increasingly used to unravel the physiology of SOM-containing neurons. However, while knock-in targeting strategy greatly improves Cre-Lox system accuracy, recent reports hav...

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Bibliographic Details
Main Authors: Cécile Viollet, Axelle Simon, Virginie Tolle, Alexandra Labarthe, Dominique Grouselle, Yann Loe-Mie, Michel Simonneau, Guillaume Martel, Jacques Epelbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Endocrinology
Subjects:
cre mice
corticosterone
growth hormone secretory patterns
hepatic expression
feminization
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00131/full

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