DEVELOPMENT OF MAGNETIC Fe3O4 NANOPARTICLES FORMATION METHOD FOR DIAGNOSIS AND TREATMENT OF CANCER DISEASES

• Main Author: Irina Andreevna Tyurikova
• Format: Article
• Language: English
• Published: Science and Innovation Center Publishing House 2018-06-01
• Series: В мире научных открытий
• Subjects: Fe3O4; магнетит; магнитные наночастицы; МРТ; гипертермия; адресная доставка лекарств; рак
• Online Access: http://journal-s.org/index.php/vmno/article/view/11032

Objective: Developing of the technique for obtaining magnetic Fe3O4 nanoparticles for the diagnosis and treatment of oncological diseases, taking into account the requirements for their physical parameters, precursors and biocompatible stabilizing substance ensuring the steadiness and stability of the composition and characteristics of the particles. Methodology: Principles, according to which the selection of the participating in the preparation of nano-sized Fe3O4 with a stable composition and characteristics precursors is carried out were indicated. The development of the method for obtaining magnetic nanoparticles was carried out according to the requirements of different medical applications. The nanoparticles were studied by X-ray diffraction analysis, microscopy and analysis of dimensional characteristics, magnetic properties of samples were investigated by using a specially designed and constructed for this purpose installation. Results: The correspondence of the Fe3O4 magnetic nanoparticles parameters (size 10–13 nm, narrow particle size distribution, specific saturation magnetization 69 – 81 G⋅сm3/g is shown, stability of the composition is provided by the sequence of the magnetic fluid preparation) and the proposed method for their preparation, developed taking into account the toxicological principles and requirements imposed on objects used in medicine, allowing to recommend the obtained nanoparticles for further clinical trials.