P53 pathway changes and their influence on chronic lymphoproliferative diseases pathogenesis

• Main Authors: P. M. Kondratovskiy, A. I. Dubikov, A. Yu. Doroshevskaya
• Format: Article
• Language: Russian
• Published: ABV-press 2014-07-01
• Series: Onkogematologiâ
• Subjects: chronic lymphoproliferative diseases; lymphomas; chronic lymphocytic leukemia; apoptosis; р53; MDM2; p21; PUMA
• Online Access: http://oncohematology.abvpress.ru/index.php/ongm/article/view/92

<p>The role of p53 family proteins, both in the pathogenesis of chronic lymphoproliferative disorders, and in aspects of the growi ng interest in the<br />therapeutic potential of so-called small molecules capable of influencing the regulatory "relationship" of p53, MDM2, p21 and P UMA is currently actively debated. The article is an attempt to summarize the data on experimental tumor and mouse models and availablen ithe l iterature results of studies using human lymphoid tumors. Prognostic significance of p53 family proteins expression in lymphoproliferativ e diseases and possible therapeutic approaches using the features of the p53 relationship with regulators and effectors genes are considered.</p>