Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice.

Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice.

BACKGROUND:The intestinal microbiota protect the host against enteric pathogens through a defense mechanism termed colonization resistance. Antibiotics excreted into the intestinal tract may disrupt colonization resistance and alter normal metabolic functions of the microbiota. We used a mouse model...

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Bibliographic Details
Main Authors: Robin L P Jump, Alex Polinkovsky, Kelly Hurless, Brett Sitzlar, Kevin Eckart, Myreen Tomas, Abhishek Deshpande, Michelle M Nerandzic, Curtis J Donskey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4079339?pdf=render

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