Pharmacokinetic of Diclofenac in the Presence and Absence of Glibenclamide in the Rat

Pharmacokinetic of Diclofenac in the Presence and Absence of Glibenclamide in the Rat

ABSTRACT - PURPOSE. There is evidence that the sulfonylurea antidiabetic agent glibenclamide reduces the analgesic action of non-steroidal anti-inflammatory drugs (NSAIDs), opioids and neuromodulators in animal models. Therefore, in view of the vast clinical uses and interactions of NSAIDs with comm...

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Bibliographic Details
Main Authors: María R. León-Reyes, Gilberto Castañeda-Hernández, Mario I Ortiz
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2009-10-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/1702

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