Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet’s Uveitis

• Main Authors: Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-03-01
• Series: Frontiers in Immunology
• Subjects: Behcet’s disease; Behcet’s uveitis; uveitis; gene polymorphism; single nucleotide polymorphism; interleukin 33
• Online Access: https://www.frontiersin.org/articles/10.3389/fimmu.2021.589639/full

Interleukin (IL)33, a member of the IL1 superfamily, functions as a nuclear factor and mediates biological effects by interacting with the ST2 receptor. Recent studies have described IL33 as an emerging pro-inflammatory cytokine in the immune system, and IL33/ST2 gene polymorphisms have been implicated in the pathogenesis of various immune diseases. However, the underlying mechanisms of IL33/ST2 in Behcet’s disease (BD) remain to be defined. Here, we investigated the association between IL33/ST2 gene polymorphisms and BD in 585 BD uveitis (BDU) patients and 834 healthy controls using Agena MassARRAY iPLEX platform. We found that rs3821204 was associated with the development of BDU. Moreover, the frequency of rs2210463 G allele was lower in patients with genital involvement. Association analysis revealed a much greater genetic difference between complete-type and incomplete-type BD groups, including three SNPs (rs7044343, rs1048274, and rs2210463). Our findings suggest that IL33/ST2 gene polymorphisms are involved in the pathogenesis of BDU. Different genetic backgrounds may exist in complete-type and incomplete-type BD patients.