Peripheral T-cell lymphoma, not otherwise specified

• Main Authors: Kunal Kishor Jha, Suresh K Gupta, Harpreet Saluja, Nuwadatta Subedi
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-01-01
• Series: Journal of Family Medicine and Primary Care
• Subjects: CHOP regimen; lymphoma; peripheral T-cell lymphoma not otherwise specified; pralatrexate
• Online Access: http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=2;spage=427;epage=430;aulast=Jha

The peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) belongs to a heterogeneous class of aggressive neoplasms. Although several morphologic subtypes of this tumor have been described, no particular genetic, immunological, or distinct clinical features define this disease. Patients can experience night sweats, fever, lymphadenopathy, weight loss, splenomegaly, and/or skin changes. Common laboratory tests reveal that patients have anemia, thrombocytosis, lymphocytosis, eosinophilia, hypergammaglobulinemia, or increased lactate dehydrogenase. In this case study, a patient presented with massive lymphadenopathy and right lower limb swelling, which he developed over 6 weeks. A tissue biopsy and supporting investigations confirmed the diagnosis of PTCL, NOS.