Progress in fundamental research: perspectives of cardiology

• Main Authors: Evgeniy Ivanovich Chazov, E I Chazov
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2009-09-01
• Series: Терапевтический архив
• Subjects: cardiovascular diseases; fundamental research
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/30462

Recent research performed in the Cardiology Research Center (CRC) and on-going studies reviewed in the article confirm the hypothesis suggested by CRC investigators about the role of a damaging action of some reactions in the body. The damage to the cell and subcell structures is done by such substances as malonic dialdehyde, methylglyoxal, active oxygen forms (nitric oxide and others). This damage can be used in diagnosis and treatment of cardiovascular diseases. A group of peptides, neuropeptide FF and its receptors in particular, are studied for regulation of the vascular tonicity and perspectives of practical application. As a result of the study of genes associated with cardiovascular diseases mixoma markers were found providing a 100% accurate diagnosis.