Prostate Cancer Metastases Are Strongly Inhibited by Agonistic Epha2 Ligands in an Orthotopic Mouse Model

Prostate Cancer Metastases Are Strongly Inhibited by Agonistic Epha2 Ligands in an Orthotopic Mouse Model

The EphA2 tyrosine kinase receptor is highly expressed in several types of solid tumors. In our recent studies, we targeted EphA2 in pancreatic cancer with agonistic agents and demonstrated that suppression of EphA2 significantly reduced cancer-cell migration in cell-based assays. In the present stu...

Full description

Bibliographic Details
Main Authors: Ahmed F. Salem, Luca Gambini, Sandrine Billet, Yu Sun, Hiromichi Oshiro, Ming Zhao, Robert M. Hoffman, Neil A. Bhowmick, Maurizio Pellecchia
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
EphA2
ephrinA1-Fc
prostate cancer
breast cancer
cell migration
metastasis
Online Access:https://www.mdpi.com/2072-6694/12/10/2854

Similar Items

Similar Items