Dopamine D4 Receptor Counteracts Morphine-Induced Changes in µ Opioid Receptor Signaling in the Striosomes of the Rat Caudate Putamen

Dopamine D4 Receptor Counteracts Morphine-Induced Changes in µ Opioid Receptor Signaling in the Striosomes of the Rat Caudate Putamen

The mu opioid receptor (MOR) is critical in mediating morphine analgesia. However, prolonged exposure to morphine induces adaptive changes in this receptor leading to the development of tolerance and addiction. In the present work we have studied whether the continuous administration of morphine ind...

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Bibliographic Details
Main Authors: Diana Suárez-Boomgaard, Belén Gago, Alejandra Valderrama-Carvajal, Ruth Roales-Buján, Kathleen Van Craenenbroeck, Jolien Duchou, Dasiel O. Borroto-Escuela, José Medina-Luque, Adelaida de la Calle, Kjell Fuxe, Alicia Rivera
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:International Journal of Molecular Sciences
Subjects:
morphine
PD168,077
µ opioid receptor
dopamine D4 receptor
G proteins
caudate putamen
striosomes
addiction
Online Access:http://www.mdpi.com/1422-0067/15/1/1481

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http://www.mdpi.com/1422-0067/15/1/1481

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