Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy of UV radiation in the etiopathogenesis of h...

Full description

Bibliographic Details
Main Authors: Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800279

Internet

http://www.sciencedirect.com/science/article/pii/S1476558613800279

Similar Items