Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus
The development of biological therapies has had an impact on the management of several medical conditions. Their use in systemic lupus erythematosus (SLE), however, remains very limited. This review has summarized the evidence on the clinical effect of biologicals in SLE. Biological drugs with a num...
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doaj-8e7a6e926314472ab1e74d9e5740f7f52021-07-14T10:34:43ZengSAGE PublishingTherapeutic Advances in Musculoskeletal Disease1759-72182019-09-011110.1177/1759720X19874309Biological therapies and their clinical impact in the treatment of systemic lupus erythematosusRosalie MagroThe development of biological therapies has had an impact on the management of several medical conditions. Their use in systemic lupus erythematosus (SLE), however, remains very limited. This review has summarized the evidence on the clinical effect of biologicals in SLE. Biological drugs with a number of targets have been studied in several phase II and III randomized controlled trials (RCTs). Positive results have been obtained in phase III RCTs with belimumab and this led to its license for active SLE. The clinical experience with belimumab has confirmed the efficacy and safety of belimumab in SLE. Promising results have been noted in phase II trials for blisibimod, sifalimumab, anifrolumab, and ustekinumab. Despite the fact that the RCTs with rituximab did not achieve their primary endpoint, clinical experience with rituximab is extensive and shows favorable clinical response in refractory renal and non-renal SLE. It is hoped that further ongoing phase III RCTs on a number of biological agents in SLE will highlight the potential role of other biologicals in the management of this challenging and heterogeneous condition.https://doi.org/10.1177/1759720X19874309 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosalie Magro |
spellingShingle |
Rosalie Magro Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus Therapeutic Advances in Musculoskeletal Disease |
author_facet |
Rosalie Magro |
author_sort |
Rosalie Magro |
title |
Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus |
title_short |
Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus |
title_full |
Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus |
title_fullStr |
Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus |
title_full_unstemmed |
Biological therapies and their clinical impact in the treatment of systemic lupus erythematosus |
title_sort |
biological therapies and their clinical impact in the treatment of systemic lupus erythematosus |
publisher |
SAGE Publishing |
series |
Therapeutic Advances in Musculoskeletal Disease |
issn |
1759-7218 |
publishDate |
2019-09-01 |
description |
The development of biological therapies has had an impact on the management of several medical conditions. Their use in systemic lupus erythematosus (SLE), however, remains very limited. This review has summarized the evidence on the clinical effect of biologicals in SLE. Biological drugs with a number of targets have been studied in several phase II and III randomized controlled trials (RCTs). Positive results have been obtained in phase III RCTs with belimumab and this led to its license for active SLE. The clinical experience with belimumab has confirmed the efficacy and safety of belimumab in SLE. Promising results have been noted in phase II trials for blisibimod, sifalimumab, anifrolumab, and ustekinumab. Despite the fact that the RCTs with rituximab did not achieve their primary endpoint, clinical experience with rituximab is extensive and shows favorable clinical response in refractory renal and non-renal SLE. It is hoped that further ongoing phase III RCTs on a number of biological agents in SLE will highlight the potential role of other biologicals in the management of this challenging and heterogeneous condition. |
url |
https://doi.org/10.1177/1759720X19874309 |
work_keys_str_mv |
AT rosaliemagro biologicaltherapiesandtheirclinicalimpactinthetreatmentofsystemiclupuserythematosus |
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