Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their a...
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/11/3202 |
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doaj-8e64a6abbfbb4ff6afa51c93f1e8e9d52021-06-01T01:16:52ZengMDPI AGMolecules1420-30492021-05-01263202320210.3390/molecules26113202Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid DerivativesAitor Maestro0Xabier del Corte1Adrián López-Francés2Edorta Martínez de Marigorta3Francisco Palacios4Javier Vicario5Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDepartamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”-Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, SpainDue to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of α-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the past few decades. In the following lines, the existing literatures for the synthesis of optically active tetrasubstituted α-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches.https://www.mdpi.com/1420-3049/26/11/3202asymmetric synthesisα-aminophosphonic acidtetrasubstituted carbonsdiastereoselectiveenantioselectiveα-aminophosphonates |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aitor Maestro Xabier del Corte Adrián López-Francés Edorta Martínez de Marigorta Francisco Palacios Javier Vicario |
| spellingShingle |
Aitor Maestro Xabier del Corte Adrián López-Francés Edorta Martínez de Marigorta Francisco Palacios Javier Vicario Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives Molecules asymmetric synthesis α-aminophosphonic acid tetrasubstituted carbons diastereoselective enantioselective α-aminophosphonates |
| author_facet |
Aitor Maestro Xabier del Corte Adrián López-Francés Edorta Martínez de Marigorta Francisco Palacios Javier Vicario |
| author_sort |
Aitor Maestro |
| title |
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives |
| title_short |
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives |
| title_full |
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives |
| title_fullStr |
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives |
| title_full_unstemmed |
Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives |
| title_sort |
asymmetric synthesis of tetrasubstituted α-aminophosphonic acid derivatives |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2021-05-01 |
| description |
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of α-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the past few decades. In the following lines, the existing literatures for the synthesis of optically active tetrasubstituted α-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches. |
| topic |
asymmetric synthesis α-aminophosphonic acid tetrasubstituted carbons diastereoselective enantioselective α-aminophosphonates |
| url |
https://www.mdpi.com/1420-3049/26/11/3202 |
| work_keys_str_mv |
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