Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.
Bibliographic Details
| Main Authors: |
Nan W. Hultgren,
Jennifer S. Fang,
Mary E. Ziegler,
Ricardo N. Ramirez,
Duc T. T. Phan,
Michaela M. S. Hatch,
Katrina M. Welch-Reardon,
Antonio E. Paniagua,
Lin S. Kim,
Nathan N. Shon,
David S. Williams,
Ali Mortazavi,
Christopher C. W. Hughes |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18633-z
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