Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.

Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.

Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells (RGCs) express high levels of Panx1 and are s...

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Bibliographic Details
Main Authors: Galina Dvoriantchikova, Dmitry Ivanov, David Barakat, Alexander Grinberg, Rong Wen, Vladlen Z Slepak, Valery I Shestopalov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3285635?pdf=render

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