HCV-Related Nervous System Disorders

HCV-Related Nervous System Disorders

Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms re...

Full description

Bibliographic Details
Main Authors: Salvatore Monaco, Sergio Ferrari, Alberto Gajofatto, Gianluigi Zanusso, Sara Mariotto
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/236148
id doaj-8e28b26e5cff47129e54fa4c18460cb5
record_format Article
spelling doaj-8e28b26e5cff47129e54fa4c18460cb52020-11-24T21:33:26ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/236148236148HCV-Related Nervous System DisordersSalvatore Monaco0Sergio Ferrari1Alberto Gajofatto2Gianluigi Zanusso3Sara Mariotto4Section of Neuropathology, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona 37134, ItalySection of Neuropathology, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona 37134, ItalySection of Neuropathology, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona 37134, ItalySection of Neuropathology, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona 37134, ItalySection of Neuropathology, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona 37134, ItalyChronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immune response with production of autoantibodies, immune complexes, and cryoglobulins. Alternative mechanisms include possible extrahepatic replication of HCV in neural tissues and the effects of circulating inflammatory cytokines and chemokines.http://dx.doi.org/10.1155/2012/236148
collection DOAJ
language English
format Article
sources DOAJ
author Salvatore Monaco
Sergio Ferrari
Alberto Gajofatto
Gianluigi Zanusso
Sara Mariotto
spellingShingle Salvatore Monaco
Sergio Ferrari
Alberto Gajofatto
Gianluigi Zanusso
Sara Mariotto
HCV-Related Nervous System Disorders
Clinical and Developmental Immunology
author_facet Salvatore Monaco
Sergio Ferrari
Alberto Gajofatto
Gianluigi Zanusso
Sara Mariotto
author_sort Salvatore Monaco
title HCV-Related Nervous System Disorders
title_short HCV-Related Nervous System Disorders
title_full HCV-Related Nervous System Disorders
title_fullStr HCV-Related Nervous System Disorders
title_full_unstemmed HCV-Related Nervous System Disorders
title_sort hcv-related nervous system disorders
publisher Hindawi Limited
series Clinical and Developmental Immunology
issn 1740-2522
1740-2530
publishDate 2012-01-01
description Chronic infection with hepatitis C virus (HCV) is associated with a wide spectrum of extrahepatic manifestations, affecting different organ systems. Neurological complications occur in a large number of patients and range from peripheral neuropathy to cognitive impairment. Pathogenetic mechanisms responsible for nervous system dysfunction are mainly related to the upregulation of the host immune response with production of autoantibodies, immune complexes, and cryoglobulins. Alternative mechanisms include possible extrahepatic replication of HCV in neural tissues and the effects of circulating inflammatory cytokines and chemokines.
url http://dx.doi.org/10.1155/2012/236148
work_keys_str_mv AT salvatoremonaco hcvrelatednervoussystemdisorders
AT sergioferrari hcvrelatednervoussystemdisorders
AT albertogajofatto hcvrelatednervoussystemdisorders
AT gianluigizanusso hcvrelatednervoussystemdisorders
AT saramariotto hcvrelatednervoussystemdisorders
_version_ 1725953306172325888

Similar Items