Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension

Exercise training increases GAD65 expression, restores the depressed GABAA receptor function within the PVN and reduces sympathetic modulation in hypertension

Abstract GABAergic inhibitory input within the paraventricular hypothalamic nucleus (PVN) plays a key role in restraining sympathetic outflow. Although experimental evidence has shown depressed GABAA receptor function plus sympathoexcitation in hypertension and augmented GABA levels with reduced sym...

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Bibliographic Details
Main Authors: Nilson C. Ferreira‐Junior, Adriana Ruggeri, Sebastião D. Silva Jr, Thais T. Zampieri, Alexandre Ceroni, Lisete C. Michelini
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Physiological Reports
Subjects:
Autonomic nervous system
bicuculline
exercise
GABAA receptors
glutamic acid decarboxylase
hypothalamus
Online Access:https://doi.org/10.14814/phy2.14107

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