Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy

Background: Rotavirus-induced gastroenteritis (RVGE) represents the most frequent form of severe gastroenteritis in children. In such a scenario, the availability of an efficient anti-Rotavirus (anti-RV) vaccine represents an effective prevention tool able to prevent those complications mainly linke...

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Main Authors: Maria R. Gualano, Robin Thomas, Renata Gili, Giacomo Scaioli, Gianluca Voglino, Carla Zotti
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Journal of Infection and Public Health
Online Access:http://www.sciencedirect.com/science/article/pii/S1876034118301126
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spelling doaj-8e1fdd5d6c6741d2bcf7b2742e8f529a2020-11-24T21:34:42ZengElsevierJournal of Infection and Public Health1876-03412018-11-01116867872Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, ItalyMaria R. Gualano0Robin Thomas1Renata Gili2Giacomo Scaioli3Gianluca Voglino4Carla Zotti5Corresponding author at: Department of Public Health,University of Turin, Via Santena 5 bis, 10126 Turin, Italy.; Department of Public Health, University of Turin, Turin, ItalyDepartment of Public Health, University of Turin, Turin, ItalyDepartment of Public Health, University of Turin, Turin, ItalyDepartment of Public Health, University of Turin, Turin, ItalyDepartment of Public Health, University of Turin, Turin, ItalyDepartment of Public Health, University of Turin, Turin, ItalyBackground: Rotavirus-induced gastroenteritis (RVGE) represents the most frequent form of severe gastroenteritis in children. In such a scenario, the availability of an efficient anti-Rotavirus (anti-RV) vaccine represents an effective prevention tool able to prevent those complications mainly linked to the moderate-severe forms of this disease, which require hospital care. The aim of the present study is to estimate the cost effectiveness of universal routine infant RV vaccination program and its budget impact on the Regional Health Service (RHS) of Piedmont, Italy, in order to evaluate the opportunity of the implementation of a national anti-Rotavirus vaccination programme. Methods: The researchers performed a cost-effectiveness analysis comparing costs and benefits of a Rotarix two-dose vaccination versus non vaccination and a budget impact analysis (BIA), complementary to the cost-effectiveness analysis. Results: Our results show that the mass implementation of an anti-RV vaccination in Piedmont, in addition to the expected public health benefits, also allows the RHS to save a considerable amount of money within a short period of time, due to the remarkable reduction of direct health costs associated with RVGE management. In fact, as the analysis shows, a universal vaccination against RV results in money-saving for the RHS already from the 2nd year (with a vaccination coverage of 50%). During the five year period, the active and free offer of the anti-RV vaccination would determine a total saving for RHS of about € 503.000. The cost-effectiveness analysis results showed a cost-saving ICER (incremental cost-effectiveness ratio) relevant to the RHS and equal to – €12.197/QALY. Conclusion: In conclusion the adoption of a universal preventive strategy for all the infants in the Piedmont Region may contribute significantly towards the control of RVGE incidence, thus allowing a noteworthy saving of economic and social resources for both the RHS and the general public. Keywords: Rotavirus, Cost-effectiveness, Economic analysis, Burden of disease, Vaccinehttp://www.sciencedirect.com/science/article/pii/S1876034118301126
collection DOAJ
language English
format Article
sources DOAJ
author Maria R. Gualano
Robin Thomas
Renata Gili
Giacomo Scaioli
Gianluca Voglino
Carla Zotti
spellingShingle Maria R. Gualano
Robin Thomas
Renata Gili
Giacomo Scaioli
Gianluca Voglino
Carla Zotti
Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy
Journal of Infection and Public Health
author_facet Maria R. Gualano
Robin Thomas
Renata Gili
Giacomo Scaioli
Gianluca Voglino
Carla Zotti
author_sort Maria R. Gualano
title Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy
title_short Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy
title_full Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy
title_fullStr Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy
title_full_unstemmed Cost-effectiveness estimates of vaccination against rotavirus in Piedmont, Italy
title_sort cost-effectiveness estimates of vaccination against rotavirus in piedmont, italy
publisher Elsevier
series Journal of Infection and Public Health
issn 1876-0341
publishDate 2018-11-01
description Background: Rotavirus-induced gastroenteritis (RVGE) represents the most frequent form of severe gastroenteritis in children. In such a scenario, the availability of an efficient anti-Rotavirus (anti-RV) vaccine represents an effective prevention tool able to prevent those complications mainly linked to the moderate-severe forms of this disease, which require hospital care. The aim of the present study is to estimate the cost effectiveness of universal routine infant RV vaccination program and its budget impact on the Regional Health Service (RHS) of Piedmont, Italy, in order to evaluate the opportunity of the implementation of a national anti-Rotavirus vaccination programme. Methods: The researchers performed a cost-effectiveness analysis comparing costs and benefits of a Rotarix two-dose vaccination versus non vaccination and a budget impact analysis (BIA), complementary to the cost-effectiveness analysis. Results: Our results show that the mass implementation of an anti-RV vaccination in Piedmont, in addition to the expected public health benefits, also allows the RHS to save a considerable amount of money within a short period of time, due to the remarkable reduction of direct health costs associated with RVGE management. In fact, as the analysis shows, a universal vaccination against RV results in money-saving for the RHS already from the 2nd year (with a vaccination coverage of 50%). During the five year period, the active and free offer of the anti-RV vaccination would determine a total saving for RHS of about € 503.000. The cost-effectiveness analysis results showed a cost-saving ICER (incremental cost-effectiveness ratio) relevant to the RHS and equal to – €12.197/QALY. Conclusion: In conclusion the adoption of a universal preventive strategy for all the infants in the Piedmont Region may contribute significantly towards the control of RVGE incidence, thus allowing a noteworthy saving of economic and social resources for both the RHS and the general public. Keywords: Rotavirus, Cost-effectiveness, Economic analysis, Burden of disease, Vaccine
url http://www.sciencedirect.com/science/article/pii/S1876034118301126
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