Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.

Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.

Colon cancer is the second most common cause of cancer mortality in the Western world with metastasis commonly present at the time of diagnosis. Screening for propagation and metastatic behavior in a novel chimeric-mouse colon cancer model, driven by mutant p53 and β-Catenin, led to the identificati...

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Bibliographic Details
Main Authors: Yinghui Zhou, William M Rideout, Angela Bressel, Sireesha Yalavarthi, Tong Zi, Darren Potz, Samuel Farlow, Joelle Brodeur, Anthony Monti, Shailaja Reddipalli, Qiurong Xiao, Steve Bottega, Bin Feng, M Isabel Chiu, Marcus Bosenberg, Joerg Heyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4146580?pdf=render

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