Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

Abstract Background Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrogens are mediated through ERβ and insulin-like growth factor 1 signaling...

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Bibliographic Details
Main Authors: Scott M. Belcher, Caleb C. Burton, Clifford J. Cookman, Michelle Kirby, Gabriel L. Miranda, Fatima O. Saeed, Kathleen E. Wray
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Pharmacology and Toxicology
Subjects:
Chemotherapy
Cytoprotection
Concentration-response
Estrogen
In vitro
Isoflavones
Online Access:http://link.springer.com/article/10.1186/s40360-017-0160-7

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