Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters

Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters

Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics and pharmacodynamics determining differences in efficacy and safety and causing inter-individual variability in drug response. Therefore, pharmacogenomics can help clinicians in optimizing therapy based on patient...

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Main Authors: Teresa Iannaccone, Carmine Sellitto, Valentina Manzo, Francesca Colucci, Valentina Giudice, Berenice Stefanelli, Antonio Iuliano, Giulio Corrivetti, Amelia Filippelli
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
pharmacogenomics
carbamazepine
valproate
mood stabilizers
Online Access:https://www.mdpi.com/1424-8247/14/3/204
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spelling doaj-8e18948a2b8141bca2fc54a0eb0f24182021-03-02T00:04:17ZengMDPI AGPharmaceuticals1424-82472021-03-011420420410.3390/ph14030204Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and TransportersTeresa Iannaccone0Carmine Sellitto1Valentina Manzo2Francesca Colucci3Valentina Giudice4Berenice Stefanelli5Antonio Iuliano6Giulio Corrivetti7Amelia Filippelli8Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyEuropean Biomedical Research Institute of Salerno (EBRIS), 84125 Salerno, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyPharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics and pharmacodynamics determining differences in efficacy and safety and causing inter-individual variability in drug response. Therefore, pharmacogenomics can help clinicians in optimizing therapy based on patient’s genotype, also in psychiatric and neurological settings. However, pharmacogenetic screenings for psychotropic drugs are not routinely employed in diagnosis and monitoring of patients treated with mood stabilizers, such as carbamazepine and valproate, because their benefit in clinical practice is still controversial. In this review, we summarize the current knowledge on pharmacogenetic biomarkers of these anticonvulsant drugs.https://www.mdpi.com/1424-8247/14/3/204pharmacogenomicscarbamazepinevalproatemood stabilizers
collection DOAJ
language English
format Article
sources DOAJ
author Teresa Iannaccone
Carmine Sellitto
Valentina Manzo
Francesca Colucci
Valentina Giudice
Berenice Stefanelli
Antonio Iuliano
Giulio Corrivetti
Amelia Filippelli
spellingShingle Teresa Iannaccone
Carmine Sellitto
Valentina Manzo
Francesca Colucci
Valentina Giudice
Berenice Stefanelli
Antonio Iuliano
Giulio Corrivetti
Amelia Filippelli
Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
Pharmaceuticals
pharmacogenomics
carbamazepine
valproate
mood stabilizers
author_facet Teresa Iannaccone
Carmine Sellitto
Valentina Manzo
Francesca Colucci
Valentina Giudice
Berenice Stefanelli
Antonio Iuliano
Giulio Corrivetti
Amelia Filippelli
author_sort Teresa Iannaccone
title Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
title_short Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
title_full Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
title_fullStr Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
title_full_unstemmed Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters
title_sort pharmacogenetics of carbamazepine and valproate: focus on polymorphisms of drug metabolizing enzymes and transporters
publisher MDPI AG
series Pharmaceuticals
issn 1424-8247
publishDate 2021-03-01
description Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics and pharmacodynamics determining differences in efficacy and safety and causing inter-individual variability in drug response. Therefore, pharmacogenomics can help clinicians in optimizing therapy based on patient’s genotype, also in psychiatric and neurological settings. However, pharmacogenetic screenings for psychotropic drugs are not routinely employed in diagnosis and monitoring of patients treated with mood stabilizers, such as carbamazepine and valproate, because their benefit in clinical practice is still controversial. In this review, we summarize the current knowledge on pharmacogenetic biomarkers of these anticonvulsant drugs.
topic pharmacogenomics
carbamazepine
valproate
mood stabilizers
url https://www.mdpi.com/1424-8247/14/3/204
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AT valentinamanzo pharmacogeneticsofcarbamazepineandvalproatefocusonpolymorphismsofdrugmetabolizingenzymesandtransporters
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