Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis.

Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis.

The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low micromolar (μM) concentrations that ranged from 1.6...

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Bibliographic Details
Main Authors: Paulina J Villanueva, Alberto Martinez, Sarah T Baca, Rebecca E DeJesus, Manuel Larragoity, Lisett Contreras, Denisse A Gutierrez, Armando Varela-Ramirez, Renato J Aguilera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6218039?pdf=render

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