Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.

Bibliographic Details
Main Authors: Céline M. Laumont, Tariq Daouda, Jean-Philippe Laverdure, Éric Bonneil, Olivier Caron-Lizotte, Marie-Pierre Hardy, Diana P. Granados, Chantal Durette, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10238

Internet

https://doi.org/10.1038/ncomms10238

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