Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.

Bibliographic Details
Main Authors:	Céline M. Laumont, Tariq Daouda, Jean-Philippe Laverdure, Éric Bonneil, Olivier Caron-Lizotte, Marie-Pierre Hardy, Diana P. Granados, Chantal Durette, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10238

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spelling	doaj-8e030826a1744d55a142f5a4d3124d1e2021-05-11T11:10:48ZengNature Publishing GroupNature Communications2041-17232016-01-017111210.1038/ncomms10238Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading framesCéline M. Laumont0Tariq Daouda1Jean-Philippe Laverdure2Éric Bonneil3Olivier Caron-Lizotte4Marie-Pierre Hardy5Diana P. Granados6Chantal Durette7Sébastien Lemieux8Pierre Thibault9Claude Perreault10Institute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalCryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.https://doi.org/10.1038/ncomms10238
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Céline M. Laumont Tariq Daouda Jean-Philippe Laverdure Éric Bonneil Olivier Caron-Lizotte Marie-Pierre Hardy Diana P. Granados Chantal Durette Sébastien Lemieux Pierre Thibault Claude Perreault
spellingShingle	Céline M. Laumont Tariq Daouda Jean-Philippe Laverdure Éric Bonneil Olivier Caron-Lizotte Marie-Pierre Hardy Diana P. Granados Chantal Durette Sébastien Lemieux Pierre Thibault Claude Perreault Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames Nature Communications
author_facet	Céline M. Laumont Tariq Daouda Jean-Philippe Laverdure Éric Bonneil Olivier Caron-Lizotte Marie-Pierre Hardy Diana P. Granados Chantal Durette Sébastien Lemieux Pierre Thibault Claude Perreault
author_sort	Céline M. Laumont
title	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_short	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_full	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_fullStr	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_full_unstemmed	Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
title_sort	global proteogenomic analysis of human mhc class i-associated peptides derived from non-canonical reading frames
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-01-01
description	Cryptic translation of the 'non-coding' genome is increasingly recognised, however its biological significance remains unclear. Laumont et al.employ proteogenomic techniques to map the human immunoproteome, and find that approximately 10% of MHC class I-associated peptides are cryptic.
url	https://doi.org/10.1038/ncomms10238
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Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames

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