Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole

Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole

The etiology of Crohn's disease (CD) remains controversial. It is hypothesized that CD is the result of an abnormal immune response to the gut flora in genetically susceptible hosts. However, an infectious etiology has not been completely ruled out. Antibiotics have been utilized with some succ...

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Bibliographic Details
Main Authors: Neil D. Goldberg, Aravinda Vadlamudi, Nicole Parrish
Format: Article
Language:English
Published: Karger Publishers 2015-01-01
Series:Case Reports in Gastroenterology
Subjects:
Combination therapy
Crohnߣs disease
Pyoderma gangrenosum
Online Access:http://www.karger.com/Article/FullText/369965
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spelling doaj-8dff0ffafc304dd9889f0debbcb3a90c2020-11-24T23:03:45ZengKarger PublishersCase Reports in Gastroenterology1662-06312015-01-0191252810.1159/000369965369965Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and MetronidazoleNeil D. GoldbergAravinda VadlamudiNicole ParrishThe etiology of Crohn's disease (CD) remains controversial. It is hypothesized that CD is the result of an abnormal immune response to the gut flora in genetically susceptible hosts. However, an infectious etiology has not been completely ruled out. Antibiotics have been utilized with some success to modify the course of the disease. Here, we report a patient with CD and pyoderma gangrenosum refractory to standard therapy, including biologics, who achieved remission with a combination of rifaximin, gentamicin and metronidazole.http://www.karger.com/Article/FullText/369965Combination therapyCrohnߣs diseasePyoderma gangrenosum
collection DOAJ
language English
format Article
sources DOAJ
author Neil D. Goldberg
Aravinda Vadlamudi
Nicole Parrish
spellingShingle Neil D. Goldberg
Aravinda Vadlamudi
Nicole Parrish
Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole
Case Reports in Gastroenterology
Combination therapy
Crohnߣs disease
Pyoderma gangrenosum
author_facet Neil D. Goldberg
Aravinda Vadlamudi
Nicole Parrish
author_sort Neil D. Goldberg
title Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole
title_short Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole
title_full Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole
title_fullStr Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole
title_full_unstemmed Treatment of Refractory Crohn's Disease and Pyoderma Gangrenosum with a Combination Regimen of Rifaximin, Gentamicin and Metronidazole
title_sort treatment of refractory crohn's disease and pyoderma gangrenosum with a combination regimen of rifaximin, gentamicin and metronidazole
publisher Karger Publishers
series Case Reports in Gastroenterology
issn 1662-0631
publishDate 2015-01-01
description The etiology of Crohn's disease (CD) remains controversial. It is hypothesized that CD is the result of an abnormal immune response to the gut flora in genetically susceptible hosts. However, an infectious etiology has not been completely ruled out. Antibiotics have been utilized with some success to modify the course of the disease. Here, we report a patient with CD and pyoderma gangrenosum refractory to standard therapy, including biologics, who achieved remission with a combination of rifaximin, gentamicin and metronidazole.
topic Combination therapy
Crohnߣs disease
Pyoderma gangrenosum
url http://www.karger.com/Article/FullText/369965
work_keys_str_mv AT neildgoldberg treatmentofrefractorycrohnsdiseaseandpyodermagangrenosumwithacombinationregimenofrifaximingentamicinandmetronidazole
AT aravindavadlamudi treatmentofrefractorycrohnsdiseaseandpyodermagangrenosumwithacombinationregimenofrifaximingentamicinandmetronidazole
AT nicoleparrish treatmentofrefractorycrohnsdiseaseandpyodermagangrenosumwithacombinationregimenofrifaximingentamicinandmetronidazole
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