The sequence of structural, functional and cognitive changes in multiple sclerosis

The sequence of structural, functional and cognitive changes in multiple sclerosis

Background: As disease progression remains poorly understood in multiple sclerosis (MS), we aim to investigate the sequence in which different disease milestones occur using a novel data-driven approach. Methods: We analysed a cohort of 295 relapse-onset MS patients and 96 healthy controls, and cons...

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Main Authors: Iris Dekker, Menno M. Schoonheim, Vikram Venkatraghavan, Anand J.C. Eijlers, Iman Brouwer, Esther E. Bron, Stefan Klein, Mike P. Wattjes, Alle Meije Wink, Jeroen J.G. Geurts, Bernard M.J. Uitdehaag, Neil P. Oxtoby, Daniel C. Alexander, Hugo Vrenken, Joep Killestein, Frederik Barkhof, Viktor Wottschel
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Multiple sclerosis
Disease progression
Disability
Cognition
MRI
Event-based modelling
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158220303879

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