SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.

SerpinB2 (PAI-2), a member of the clade B family of serine protease inhibitors, is one of the most upregulated proteins following cellular stress. Originally described as an inhibitor of urokinase plasminogen activator, its predominant cytoplasmic localisation suggests an intracellular function. Ser...

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Bibliographic Details
Main Authors: Jodi A Lee, Justin J Yerbury, Natalie Farrawell, Robert F Shearer, Patrick Constantinescu, Danny M Hatters, Wayne A Schroder, Andreas Suhrbier, Mark R Wilson, Darren N Saunders, Marie Ranson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4470917?pdf=render

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