Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Protect Cardiomyocytes from Doxorubicin-Induced Cardiomyopathy by Upregulating Survivin Expression via the miR-199a-3p-Akt-Sp1/p53 Signaling Pathway

Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Protect Cardiomyocytes from Doxorubicin-Induced Cardiomyopathy by Upregulating Survivin Expression via the miR-199a-3p-Akt-Sp1/p53 Signaling Pathway

Cardiotoxicity is associated with the long-term clinical application of doxorubicin (DOX) in cancer patients. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) including exosomes have been suggested for the treatment of various diseases, including ischemic diseases. However, the...

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Bibliographic Details
Main Authors: Ji Yoon Lee, Jihwa Chung, Yeongju Byun, Kyoung Hwa Kim, Shung Hyun An, Kihwan Kwon
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
MSC-sEVs
doxorubicin-induced cardiomyopathy
survivin
miRNA
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/13/7102

Internet

https://www.mdpi.com/1422-0067/22/13/7102

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