Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury

Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury

Abstract Background Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have shown great potential in spinal cord injury (SCI) treatment. This research was designed to investigate the therapeutic effects of miR-26a-modified MSC-derived exosomes (Exos-26a) following SCI. Methods Bioinfo...

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Bibliographic Details
Main Authors: Yuyong Chen, Zhenming Tian, Lei He, Can Liu, Nangxiang Wang, Limin Rong, Bin Liu
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Exosomes
Spinal cord injury
Axonal regeneration
miR-26a/PTEN axis
Online Access:https://doi.org/10.1186/s13287-021-02282-0

Internet

https://doi.org/10.1186/s13287-021-02282-0

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