The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.

Bibliographic Details
Main Authors: Jason Ziveri, Fabiola Tros, Ida Chiara Guerrera, Cerina Chhuon, Mathilde Audry, Marion Dupuis, Monique Barel, Sarantis Korniotis, Simon Fillatreau, Lara Gales, Edern Cahoreau, Alain Charbit
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00889-7
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spelling doaj-8dc1a270813149de956d15a4be2abb182021-05-11T07:35:07ZengNature Publishing GroupNature Communications2041-17232017-10-018111510.1038/s41467-017-00889-7The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic FrancisellaJason Ziveri0Fabiola Tros1Ida Chiara Guerrera2Cerina Chhuon3Mathilde Audry4Marion Dupuis5Monique Barel6Sarantis Korniotis7Simon Fillatreau8Lara Gales9Edern Cahoreau10Alain Charbit11Université Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéUniversité Paris Descartes, Sorbonne Paris CitéMetatoul Platform, LISBP, Université de Toulouse, CNRS, INRA, INSAMetatoul Platform, LISBP, Université de Toulouse, CNRS, INRA, INSAUniversité Paris Descartes, Sorbonne Paris CitéThe enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.https://doi.org/10.1038/s41467-017-00889-7
collection DOAJ
language English
format Article
sources DOAJ
author Jason Ziveri
Fabiola Tros
Ida Chiara Guerrera
Cerina Chhuon
Mathilde Audry
Marion Dupuis
Monique Barel
Sarantis Korniotis
Simon Fillatreau
Lara Gales
Edern Cahoreau
Alain Charbit
spellingShingle Jason Ziveri
Fabiola Tros
Ida Chiara Guerrera
Cerina Chhuon
Mathilde Audry
Marion Dupuis
Monique Barel
Sarantis Korniotis
Simon Fillatreau
Lara Gales
Edern Cahoreau
Alain Charbit
The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
Nature Communications
author_facet Jason Ziveri
Fabiola Tros
Ida Chiara Guerrera
Cerina Chhuon
Mathilde Audry
Marion Dupuis
Monique Barel
Sarantis Korniotis
Simon Fillatreau
Lara Gales
Edern Cahoreau
Alain Charbit
author_sort Jason Ziveri
title The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_short The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_full The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_fullStr The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_full_unstemmed The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_sort metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic francisella
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.
url https://doi.org/10.1038/s41467-017-00889-7
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