PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly
Summary: The regulation of mitochondrial RNA life cycles and their roles in ribosome biogenesis and energy metabolism are not fully understood. We used CRISPR/Cas9 to generate heart- and skeletal-muscle-specific knockout mice of the pentatricopeptide repeat domain protein 1, PTCD1, and show that its...
Main Authors: | Kara L. Perks, Giulia Rossetti, Irina Kuznetsova, Laetitia A. Hughes, Judith A. Ermer, Nicola Ferreira, Jakob D. Busch, Danielle L. Rudler, Henrik Spahr, Thomas Schöndorf, Ann-Marie J. Shearwood, Helena M. Viola, Stefan J. Siira, Livia C. Hool, Dusanka Milenkovic, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2018-04-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718303759 |
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