THE USE OF HOMOLOGOUS CELLULAR PEPTIDES DURING MEDIUM-TERM CORNEAL ORGAN CULTURE AND CORNEAL COLD STORAGE

• Main Authors: S.A. Borzenok, O.I. Rolik, N.A. Onischenko, Y.A. Komakh, V.V. Delektorskaya
• Format: Article
• Language: Russian
• Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 2012-03-01
• Series: Vestnik Transplantologii i Iskusstvennyh Organov
• Subjects: cornea endothelium cells, corneal graft, cytoplasm peptides, regulatory peptides, cornea preservation.
• Online Access: https://journal.transpl.ru/vtio/article/view/117
• ISSN: 1995-1191

There was studied of protective effects of homologous cellular peptides on corneal graft endothelium cells during the corneal organ culture (24 days) and corneal cold storage (9 days). The dynamic of endothelial cells (EC) ultrastuktural changes during the storage, decrease of endothelial cells density, percentage of hexagonal-shape cells, average area and electronic microscopy were analised. Tissue-specific regulatory corneal peptides exhibited clear protective effect on ultra structure of grafts’ endothelial cells during the preservation, increase density cell-cell contact, prolong term of organ culture (till 16 days) and cold storage (till 9 days).