Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice.

Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice.

OBJECTIVE: Functional studies show that disruption of endothelial surface layer (ESL) is accompanied by enhanced sensitivity of the vasculature towards atherogenic stimuli. However, relevance of ESL disruption as causal mechanism for vascular dysfunction remains to be demonstrated. We examined if lo...

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Bibliographic Details
Main Authors: Marijn C Meuwese, Lysette N Broekhuizen, Mayella Kuikhoven, Sylvia Heeneman, Esther Lutgens, Marion J J Gijbels, Max Nieuwdorp, Carine J Peutz, Erik S G Stroes, Hans Vink, Bernard M van den Berg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2999536?pdf=render

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http://europepmc.org/articles/PMC2999536?pdf=render

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