Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration
The linear range of the non-enzymatic glucose sensor is usually much smaller than the glucose level of diabetic patients, calling for an effective solution. Despite many previous attempts, none have solved the problem. Such a challenge has now been conquered by raising the NaOH concentration in the...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Crystals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4352/10/3/186 |
| id |
doaj-8dac4e8cb35b46a4882ba773510ca6fd |
|---|---|
| record_format |
Article |
| spelling |
doaj-8dac4e8cb35b46a4882ba773510ca6fd2020-11-25T02:27:36ZengMDPI AGCrystals2073-43522020-03-0110318610.3390/cryst10030186cryst10030186Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> ConcentrationLory Wenjuan Yang0Elton Enchong Liu1Alex Fan Xu2Jason Yuanzhe Chen3Ryan Taoran Wang4Gu Xu5Department of Materials Science and Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, CanadaDepartment of Materials Science and Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, CanadaDepartment of Materials Science and Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, CanadaDepartment of Materials Science and Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, CanadaDepartment of Materials Science and Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, CanadaDepartment of Materials Science and Engineering, McMaster University, 1280 Main St. W, Hamilton, ON L8S 4L8, CanadaThe linear range of the non-enzymatic glucose sensor is usually much smaller than the glucose level of diabetic patients, calling for an effective solution. Despite many previous attempts, none have solved the problem. Such a challenge has now been conquered by raising the NaOH concentration in the electrolyte, where amperometry, X-ray diffraction, Fourier-transform infrared spectroscopy, and Nuclear magnetic resonance measurements have been conducted. The linear range has been successfully enhanced to 40 mM in 1000 mM NaOH solution, and it was also found that NaOH affected the degree of glucose oxidation, which influenced the current response during sensing. It was expected that the alkaline concentration must be 25 times higher than the glucose concentration to enhance the linear range, much contrary to prior understanding.https://www.mdpi.com/2073-4352/10/3/186non-enzymatic glucose sensorlinear rangemechanism |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lory Wenjuan Yang Elton Enchong Liu Alex Fan Xu Jason Yuanzhe Chen Ryan Taoran Wang Gu Xu |
| spellingShingle |
Lory Wenjuan Yang Elton Enchong Liu Alex Fan Xu Jason Yuanzhe Chen Ryan Taoran Wang Gu Xu Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration Crystals non-enzymatic glucose sensor linear range mechanism |
| author_facet |
Lory Wenjuan Yang Elton Enchong Liu Alex Fan Xu Jason Yuanzhe Chen Ryan Taoran Wang Gu Xu |
| author_sort |
Lory Wenjuan Yang |
| title |
Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration |
| title_short |
Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration |
| title_full |
Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration |
| title_fullStr |
Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration |
| title_full_unstemmed |
Improving Linear Range Limitation of Non-Enzymatic Glucose Sensor by OH<sup>−</sup> Concentration |
| title_sort |
improving linear range limitation of non-enzymatic glucose sensor by oh<sup>−</sup> concentration |
| publisher |
MDPI AG |
| series |
Crystals |
| issn |
2073-4352 |
| publishDate |
2020-03-01 |
| description |
The linear range of the non-enzymatic glucose sensor is usually much smaller than the glucose level of diabetic patients, calling for an effective solution. Despite many previous attempts, none have solved the problem. Such a challenge has now been conquered by raising the NaOH concentration in the electrolyte, where amperometry, X-ray diffraction, Fourier-transform infrared spectroscopy, and Nuclear magnetic resonance measurements have been conducted. The linear range has been successfully enhanced to 40 mM in 1000 mM NaOH solution, and it was also found that NaOH affected the degree of glucose oxidation, which influenced the current response during sensing. It was expected that the alkaline concentration must be 25 times higher than the glucose concentration to enhance the linear range, much contrary to prior understanding. |
| topic |
non-enzymatic glucose sensor linear range mechanism |
| url |
https://www.mdpi.com/2073-4352/10/3/186 |
| work_keys_str_mv |
AT lorywenjuanyang improvinglinearrangelimitationofnonenzymaticglucosesensorbyohsupsupconcentration AT eltonenchongliu improvinglinearrangelimitationofnonenzymaticglucosesensorbyohsupsupconcentration AT alexfanxu improvinglinearrangelimitationofnonenzymaticglucosesensorbyohsupsupconcentration AT jasonyuanzhechen improvinglinearrangelimitationofnonenzymaticglucosesensorbyohsupsupconcentration AT ryantaoranwang improvinglinearrangelimitationofnonenzymaticglucosesensorbyohsupsupconcentration AT guxu improvinglinearrangelimitationofnonenzymaticglucosesensorbyohsupsupconcentration |
| _version_ |
1724842109306929152 |