Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evol...

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Main Authors:	Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25810-1

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spelling	doaj-8daa3afd4ca340eaad289f8348f3805b2021-09-26T11:45:18ZengNature Publishing GroupNature Communications2041-17232021-09-0112111710.1038/s41467-021-25810-1Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticityJonas Malkmus0Laurène Ramos Martins1Shalu Jhanwar2Bonnie Kircher3Victorio Palacio4Rushikesh Sheth5Francisca Leal6Amandine Duchesne7Javier Lopez-Rios8Kevin A. Peterson9Robert Reinhardt10Koh Onimaru11Martin J. Cohn12Aimée Zuniga13Rolf Zeller14Developmental Genetics, Department of Biomedicine, University of BaselDevelopmental Genetics, Department of Biomedicine, University of BaselDevelopmental Genetics, Department of Biomedicine, University of BaselDepartment of Biology, University of FloridaDevelopmental Genetics, Department of Biomedicine, University of BaselDevelopmental Genetics, Department of Biomedicine, University of BaselDepartment of Biology, University of FloridaUniversité Paris-Saclay, INRAE, AgroParisTech, GABIDevelopment and Evolution, Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide-Junta de AndalucíaThe Jackson LaboratoryDevelopmental Genetics, Department of Biomedicine, University of BaselLaboratory for Bioinformatics Research, RIKEN BDRDepartment of Biology, University of FloridaDevelopmental Genetics, Department of Biomedicine, University of BaselDevelopmental Genetics, Department of Biomedicine, University of BaselThe BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evolutionary plasticity.https://doi.org/10.1038/s41467-021-25810-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jonas Malkmus Laurène Ramos Martins Shalu Jhanwar Bonnie Kircher Victorio Palacio Rushikesh Sheth Francisca Leal Amandine Duchesne Javier Lopez-Rios Kevin A. Peterson Robert Reinhardt Koh Onimaru Martin J. Cohn Aimée Zuniga Rolf Zeller
spellingShingle	Jonas Malkmus Laurène Ramos Martins Shalu Jhanwar Bonnie Kircher Victorio Palacio Rushikesh Sheth Francisca Leal Amandine Duchesne Javier Lopez-Rios Kevin A. Peterson Robert Reinhardt Koh Onimaru Martin J. Cohn Aimée Zuniga Rolf Zeller Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity Nature Communications
author_facet	Jonas Malkmus Laurène Ramos Martins Shalu Jhanwar Bonnie Kircher Victorio Palacio Rushikesh Sheth Francisca Leal Amandine Duchesne Javier Lopez-Rios Kevin A. Peterson Robert Reinhardt Koh Onimaru Martin J. Cohn Aimée Zuniga Rolf Zeller
author_sort	Jonas Malkmus
title	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_short	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_full	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_fullStr	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_full_unstemmed	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_sort	spatial regulation by multiple gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evolutionary plasticity.
url	https://doi.org/10.1038/s41467-021-25810-1
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Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

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