Polyol Pathway Exacerbated Ischemia/Reperfusion-Induced Injury in Steatotic Liver

Background. The polyol pathway, a bypass pathway of glucose metabolism initiated by aldose reductase (AR), has been shown to play an important role in mediating tissue ischemia/reperfusion (I/R) impairment recently. Here, we investigated how and why this pathway might affect the fatty liver followin...

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Bibliographic Details
Main Authors: Changhe Zhang, Changjun Huang, Yuan Tian, Xiangcheng Li
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2014/963629