The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine

The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine

Abstract Background Use of the antipsychotic drug olanzapine by patients with schizophrenia is associated with autonomic nervous system (ANS) dysfunction. It is presumed that there are interindividual differences in ANS dysfunction that correspond to pharmacogenetics. In this study, we investigated...

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Bibliographic Details
Main Authors: Saki Hattori, Akira Suda, Masatoshi Miyauchi, Yohko Shiraishi, Takashi Saeki, Tadashi Fukushima, Mami Fujibayashi, Natsuki Tsujita, Chie Ishii, Norio Ishii, Tosiho Moritani, Yusuke Saigusa, Ikuko Kishida
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Psychiatry
Subjects:
Schizophrenia
Olanzapine
Autonomic nervous system
UGT1A4
Gene polymorphism
Heart rate variability
Online Access:http://link.springer.com/article/10.1186/s12888-020-02492-5

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http://link.springer.com/article/10.1186/s12888-020-02492-5

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