MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005

MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005

Background: Increased secretion of mucus is a hallmark of many respiratory diseases and contributes significantly to the airflow limitation experienced by many patients. While the current pharmacological approach to reducing mucus and sputum production in patients is limited, clinical studies have s...

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Main Authors: Patricia Roger, Jean-Pierre Gascard, Jacques Bara, Vincent Thomas de Montpreville, Charles Brink
Format: Article
Language:English
Published: Hindawi Limited 2001-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629350124329
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spelling doaj-8d98e47d2f034dcbb22e59988ec783ba2020-11-24T22:37:37ZengHindawi LimitedMediators of Inflammation0962-93511466-18612001-01-01101333610.1080/09629350124329MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005Patricia Roger0Jean-Pierre Gascard1Jacques Bara2Vincent Thomas de Montpreville3Charles Brink4Laboratoire de Pharmacologie Pulmonaire, CNRS-ESA 8078, Hôpital Marie Lannelongue, 133 av. de la Résistance, Le Plessis Robinson, 92350, FranceLaboratoire de Pharmacologie Pulmonaire, CNRS-ESA 8078, Hôpital Marie Lannelongue, 133 av. de la Résistance, Le Plessis Robinson, 92350, FranceLaboratoire de Anatomopathologie, Hôpital Marie Lannelongue, 133 av. de la Résistance, Le Plessis Robinson, 92350, FranceINSERM U482, Hôpital Saint Antoine, 184 rue du Faubourg Saint Antoine, Paris 75012, FranceLaboratoire de Pharmacologie Pulmonaire, CNRS-ESA 8078, Hôpital Marie Lannelongue, 133 av. de la Résistance, Le Plessis Robinson, 92350, FranceBackground: Increased secretion of mucus is a hallmark of many respiratory diseases and contributes significantly to the airflow limitation experienced by many patients. While the current pharmacological approach to reducing mucus and sputum production in patients is limited, clinical studies have suggested that drugs which inhibit the cyclooxygenase and/or 5-lipoxygenase enzymatic pathways may reduce secretory activity in patients with airway disease.http://dx.doi.org/10.1080/09629350124329
collection DOAJ
language English
format Article
sources DOAJ
author Patricia Roger
Jean-Pierre Gascard
Jacques Bara
Vincent Thomas de Montpreville
Charles Brink
spellingShingle Patricia Roger
Jean-Pierre Gascard
Jacques Bara
Vincent Thomas de Montpreville
Charles Brink
MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
Mediators of Inflammation
author_facet Patricia Roger
Jean-Pierre Gascard
Jacques Bara
Vincent Thomas de Montpreville
Charles Brink
author_sort Patricia Roger
title MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
title_short MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
title_full MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
title_fullStr MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
title_full_unstemmed MUC5AC mucin release from human airways in vitro: Effects of indomethacin and Bay X1005
title_sort muc5ac mucin release from human airways in vitro: effects of indomethacin and bay x1005
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2001-01-01
description Background: Increased secretion of mucus is a hallmark of many respiratory diseases and contributes significantly to the airflow limitation experienced by many patients. While the current pharmacological approach to reducing mucus and sputum production in patients is limited, clinical studies have suggested that drugs which inhibit the cyclooxygenase and/or 5-lipoxygenase enzymatic pathways may reduce secretory activity in patients with airway disease.
url http://dx.doi.org/10.1080/09629350124329
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AT jeanpierregascard muc5acmucinreleasefromhumanairwaysinvitroeffectsofindomethacinandbayx1005
AT jacquesbara muc5acmucinreleasefromhumanairwaysinvitroeffectsofindomethacinandbayx1005
AT vincentthomasdemontpreville muc5acmucinreleasefromhumanairwaysinvitroeffectsofindomethacinandbayx1005
AT charlesbrink muc5acmucinreleasefromhumanairwaysinvitroeffectsofindomethacinandbayx1005
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