Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals

Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals

Hedgehog signaling plays very important roles in development and cancers. Vertebrates have three transcriptional factors, Gli1, Gli2 and Gli3. Among them, Gli3 is a very special transcriptional factor which closely resembles Cubitus interruptus (Ci, in Drosophila) structurally and functionally as a...

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Bibliographic Details
Main Authors: Lin Fu, Hailong Wu, Steven Y Cheng, Daming Gao, Lei Zhang, Yun Zhao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
hedgehog signaling
Gli3
Set7
methylation
tumorigenesis
Online Access:https://elifesciences.org/articles/15690

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