Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo

Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo

Osteoarthritis (OA) is a degenerative disease found in middle-aged and elderly people, which seriously affects their quality of life. The anti-inflammatory and anti-apoptosis pharmacological effects of salvianolic acid A (SAA) have been shown in many studies. In this study, we intended to explore th...

Full description

Bibliographic Details
Main Authors:	Yifan Wu, Zhanghong Wang, Zeng Lin, Xin Fu, Jingdi Zhan, Kehe Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Series:	Frontiers in Pharmacology
Subjects:	salvianolic acid A chondrocytes osteoarthritis inflammatory apoptosis MAPK
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00682/full

Similar Items

Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway
by: Jing-yi Zhang, et al.
Published: (2017-04-01)

Membrane-Free Stem Cell Components Inhibit Interleukin-1α-Stimulated Inflammation and Cartilage Degradation In Vitro and In Vivo: A Rat Model of Osteoarthritis
by: Ho Jeong Lee, et al.
Published: (2019-09-01)

Pathological perspective of chondrocyte apoptosis in osteoarthritis
by: Abhijeet Kunwar, et al.
Published: (2017-01-01)

EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway
by: Shoubao Wang, et al.
Published: (2013-02-01)

The Role of Autophagy in Osteoarthritis
by: Ran Duan, et al.
Published: (2020-11-01)

Chondrocytes apoptosis in osteoarthritis
by: Sabina Galiniak, et al.
Published: (2018-01-01)

The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation <it>in vitro</it>
by: Baier Clemens, et al.
Published: (2011-07-01)

Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways
by: Feng S, et al.
Published: (2020-05-01)

Possible applications of salvianolic acid B against different cancers
by: Iram Shahzadi, et al.
Published: (2020-08-01)

Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
by: Edith Charlier, et al.
Published: (2016-12-01)

Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice
by: Zhen Yang, et al.
Published: (2021-03-01)

Research progress on pharmacological effect of Salvianolic acid for injection in post-stroke depression
by: Wen Gu, et al.
Published: (2020-05-01)

Inhibition of Tanshinone IIA, Salvianolic Acid A and Salvianolic Acid B on Areca Nut Extract-Induced Oral Submucous Fibrosis in Vitro
by: Jian-Ping Dai, et al.
Published: (2015-04-01)

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
by: Giuseppe Musumeci, et al.
Published: (2015-08-01)

Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo
by: Pang Z, et al.
Published: (2021-09-01)

Salvianolic acid B: In vitro and in vivo effects on the immune system
by: Vujičić Milica, et al.
Published: (2017-01-01)

Effect of salvianolate therapy on peripheral blood Bcl-2, BAX and Caspase-3 expression in patients with cerebral ischemic stroke and their correlation with neural function
by: Gui-Bin Wen
Published: (2017-05-01)

Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin
by: Tenghui Tao, et al.
Published: (2021-04-01)

The function of lncRNAs in the pathogenesis of osteoarthritis
by: Chao Peng He, et al.
Published: (2021-02-01)

Effects of salvianolate on microcirculatory disturbance in patients with stable coronary heart disease: study protocol for a randomized controlled trial
by: Zhanlu Li, et al.
Published: (2021-03-01)

Neutrophil Elastase Induces Chondrocyte Apoptosis and Facilitates the Occurrence of Osteoarthritis via Caspase Signaling Pathway
by: Ganyu Wang, et al.
Published: (2021-04-01)

Biological roles and therapeutic potential of circular RNAs in osteoarthritis
by: Xingjia Mao, et al.
Published: (2021-06-01)

Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation
by: Huaming Xue, et al.
Published: (2015-07-01)

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
by: Ran J, et al.
Published: (2018-05-01)

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes
by: Shuang Liang, et al.
Published: (2018-11-01)

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy
by: Jinti Lin, et al.
Published: (2018-10-01)

The protective effect of Ellagic acid (EA) in osteoarthritis: An in vitro and in vivo study
by: Zeng Lin, et al.
Published: (2020-05-01)

Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis
by: Goncalo Barreto, et al.
Published: (2020-03-01)

Mitochondrial dependent pathway is involved in the protective effects of carboxymethylated chitosan on nitric oxide-induced apoptosis in chondrocytes
by: Bin He, et al.
Published: (2020-01-01)

Changes in plaque stability, cell apoptosis and coagulation indexes after patients with unstable angina pectoris accept adjuvant salvianolate therapy
by: Shan-Shan Xiao, et al.
Published: (2017-05-01)

Anti-Inflammatory Performance of Lactose-Modified Chitosan and Hyaluronic Acid Mixtures in an In Vitro Macrophage-Mediated Inflammation Osteoarthritis Model
by: Elena Tarricone, et al.
Published: (2020-05-01)

Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx
by: Yingliang Wei, et al.
Published: (2018-03-01)

Increased Chondrocyte Apoptosis Is Associated with Progression of Osteoarthritis in Spontaneous Guinea Pig Models of the Disease
by: Mohammed Sharif, et al.
Published: (2013-08-01)

Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation
by: Xiaoliang Mei, et al.
Published: (2021-01-01)

Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway
by: Wu Q, et al.
Published: (2020-04-01)

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
by: Hyun Sook Hwang, et al.
Published: (2015-10-01)

Effect of salvianolate injection adjuvant therapy on patients with cerebral infarction
by: Hong-Mei Liu, et al.
Published: (2016-03-01)

Salvianolic Acid B Protects Against Fatty Acid-Induced Renal Tubular Injury via Inhibition of Endoplasmic Reticulum Stress
by: Xiaoyi Mai, et al.
Published: (2020-12-01)

A Novel Synthesized Sulfonamido-Based Gallate-JEZTC Blocks Cartilage Degradation on Rabbit Model of Osteoarthritis: An in Vitro and in Vivo Study
by: Zhenhui Lu, et al.
Published: (2018-09-01)

Effects of salvianolate on bone metabolism in glucocorticoid-treated lupus-prone B6.MRL-Faslpr/J mice
by: Liu Y, et al.
Published: (2016-08-01)