Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.

Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.

Oxidative stress enhances inflammation and reduces the effectiveness of corticosteroids, but the inflammatory signalling pathways induced by oxidants remain ill-defined. Phosphorylation of histone 3 at serine 10 (H3-Pser10) marks out a subset of inflammatory genes for transcription, several of which...

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Bibliographic Details
Main Authors: John A Marwick, Corina Tudor, Nadia Khorasani, Charalambos Michaeloudes, Pankaj K Bhavsar, Kian F Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4407905?pdf=render

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http://europepmc.org/articles/PMC4407905?pdf=render

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