Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

Abstract The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elements to promote immunosuppressive outcomes. Decodi...

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Bibliographic Details
Main Authors: Somshuvra Bhattacharya, Kristin Calar, Pilar de la Puente
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Tumor microenvironment
Three-dimensional
In vitro models
Hypoxia
Immune
Bioengineering
Online Access:http://link.springer.com/article/10.1186/s13046-020-01583-1

Internet

http://link.springer.com/article/10.1186/s13046-020-01583-1

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