Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt

Background: The aim of this study was to detect the prevalence of thyroid abnormalities among children and adolescents with type 1 diabetes mellitus (T1DM) in Upper Egypt and its relationship with disease-related variables. Design: Cross-sectional controlled study. Patients and Methods: The study in...

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Main Authors: Kotb Abbass Metwalley, Abdel-Rahman Abdel-Hamed El-Saied
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Indian Journal of Endocrinology and Metabolism
Subjects:
Online Access:http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=5;spage=637;epage=641;aulast=Metwalley
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spelling doaj-8d7e594aa792405998fda365802a74a52020-11-24T23:08:55ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002014-01-0118563764110.4103/2230-8210.139218Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper EgyptKotb Abbass MetwalleyAbdel-Rahman Abdel-Hamed El-SaiedBackground: The aim of this study was to detect the prevalence of thyroid abnormalities among children and adolescents with type 1 diabetes mellitus (T1DM) in Upper Egypt and its relationship with disease-related variables. Design: Cross-sectional controlled study. Patients and Methods: The study included 94 children and adolescents with T1DM (Group 1) attending for regular follow-up in the diabetes clinic of Assiut Children University Hospital, Assiut, Egypt were enrolled in the study and 60 healthy subjects matching in age and sex were taken as a control (Group 2). History taking, clinical examination, measurement of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine, anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies levels as well as HbA1c were measured Results: Mean TSH levels were significantly higher in (Group 1) when compared to control (P < 0.01). Six children (6.3%) were found to have subclinical hypothyroidism in Group 1 compared with two children (2.1%) in the control group (P < 0.001) two children (2.1%) were found to have clinical hypothyroidism in Group 1 compared with non in the control group. Positive levels of anti-TPOAb and anti-TgAb were found in 9 (9.5%) and 6 (6.3%) in Group 1 compared with 2 (3.3)% and 1 (1.6%) of controls respectively (P < 0.01). Cases with hypothyroidism were significantly older, had longer duration of DM, higher body mass index and higher HbA1c compared with those without hypothyroidism. TSH had significant positive correlations to age (r = 0.71, P < 0.001), diabetes duration (r = 0.770, P < 0.001), Anti-TPO level (r = 0.678, P < 0.01), HbAIc level (r = −0.644, P < 0.01) and significant negative correlation with FT4 (r = −0.576, P = 0.01). Conclusion: The present study reported high prevalence of thyroid abnormalities in children and in children and adolescents with type 1 diabetes in Upper Egypt. The study recommended yearly evaluation thyroid function tests and thyroid antibodies in all children and adolescents with type 1 diabetes commencing from the onset of diabetes.http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=5;spage=637;epage=641;aulast=MetwalleyAnti-thyroid peroxidase antibody and anti-thyroglobulin antibodyhypothyroidismthyroid stimulating hormonetype I diabetes mellitus
collection DOAJ
language English
format Article
sources DOAJ
author Kotb Abbass Metwalley
Abdel-Rahman Abdel-Hamed El-Saied
spellingShingle Kotb Abbass Metwalley
Abdel-Rahman Abdel-Hamed El-Saied
Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt
Indian Journal of Endocrinology and Metabolism
Anti-thyroid peroxidase antibody and anti-thyroglobulin antibody
hypothyroidism
thyroid stimulating hormone
type I diabetes mellitus
author_facet Kotb Abbass Metwalley
Abdel-Rahman Abdel-Hamed El-Saied
author_sort Kotb Abbass Metwalley
title Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt
title_short Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt
title_full Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt
title_fullStr Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt
title_full_unstemmed Thyroid abnormalities in Egyptian children and adolescents with type 1 diabetes mellitus: A single center study from Upper Egypt
title_sort thyroid abnormalities in egyptian children and adolescents with type 1 diabetes mellitus: a single center study from upper egypt
publisher Wolters Kluwer Medknow Publications
series Indian Journal of Endocrinology and Metabolism
issn 2230-8210
2230-9500
publishDate 2014-01-01
description Background: The aim of this study was to detect the prevalence of thyroid abnormalities among children and adolescents with type 1 diabetes mellitus (T1DM) in Upper Egypt and its relationship with disease-related variables. Design: Cross-sectional controlled study. Patients and Methods: The study included 94 children and adolescents with T1DM (Group 1) attending for regular follow-up in the diabetes clinic of Assiut Children University Hospital, Assiut, Egypt were enrolled in the study and 60 healthy subjects matching in age and sex were taken as a control (Group 2). History taking, clinical examination, measurement of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine, anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies levels as well as HbA1c were measured Results: Mean TSH levels were significantly higher in (Group 1) when compared to control (P < 0.01). Six children (6.3%) were found to have subclinical hypothyroidism in Group 1 compared with two children (2.1%) in the control group (P < 0.001) two children (2.1%) were found to have clinical hypothyroidism in Group 1 compared with non in the control group. Positive levels of anti-TPOAb and anti-TgAb were found in 9 (9.5%) and 6 (6.3%) in Group 1 compared with 2 (3.3)% and 1 (1.6%) of controls respectively (P < 0.01). Cases with hypothyroidism were significantly older, had longer duration of DM, higher body mass index and higher HbA1c compared with those without hypothyroidism. TSH had significant positive correlations to age (r = 0.71, P < 0.001), diabetes duration (r = 0.770, P < 0.001), Anti-TPO level (r = 0.678, P < 0.01), HbAIc level (r = −0.644, P < 0.01) and significant negative correlation with FT4 (r = −0.576, P = 0.01). Conclusion: The present study reported high prevalence of thyroid abnormalities in children and in children and adolescents with type 1 diabetes in Upper Egypt. The study recommended yearly evaluation thyroid function tests and thyroid antibodies in all children and adolescents with type 1 diabetes commencing from the onset of diabetes.
topic Anti-thyroid peroxidase antibody and anti-thyroglobulin antibody
hypothyroidism
thyroid stimulating hormone
type I diabetes mellitus
url http://www.ijem.in/article.asp?issn=2230-8210;year=2014;volume=18;issue=5;spage=637;epage=641;aulast=Metwalley
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AT abdelrahmanabdelhamedelsaied thyroidabnormalitiesinegyptianchildrenandadolescentswithtype1diabetesmellitusasinglecenterstudyfromupperegypt
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