Pancreatic GLP-1r binding potential is reduced in insulin-resistant pigs

Introduction The insulinotropic capacity of exogenous glucagon like peptide-1 (GLP-1) is reduced in type 2 diabetes and the insulin-resistant obese. We have tested the hypothesis that this response is the consequence of a reduced pancreatic GLP-1 receptor (GLP-1r) density in insulin-resistant obese...

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Bibliographic Details
Main Authors: Charles-Henri Malbert, Alain Chauvin, Michael Horowitz, Karen L Jones
Format: Article
Language:English
Published: BMJ Publishing Group 2020-12-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/8/2/e001540.full