The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons

The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons

N-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate. In cholinergic neurons, acetyl-CoA is also utilized in the mitochondrial tricarboxylic acid cycle and in acetylcholine production pathways. While aspartate has to be shared with the malate–...

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Bibliographic Details
Main Authors: Marlena Zyśk, Monika Sakowicz-Burkiewicz, Piotr Pikul, Robert Kowalski, Anna Michno, Tadeusz Pawełczyk
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
2-APB
zinc neurotoxicity
diabetes
Online Access:https://www.mdpi.com/2076-3921/9/6/522

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