Morphological and lipid analysis of the alveolar lining material in dog lung

Endobronchial saline lavage was used to obtain acellular material and cells from the dog lung. The centrifuged lavage fluid yielded a sediment consisting of an upper white layer and a lower brown layer. The white layer was strongly surface-active. It consisted of a mixture of lipids and proteins; th...

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Bibliographic Details
Main Authors:	T.N. Finley, S.A. Pratt, A.J. Ladman, L. Brewer, M.B. McKay
Format:	Article
Language:	English
Published:	Elsevier 1968-05-01
Series:	Journal of Lipid Research
Subjects:	endobronchial lavage pulmonary surfactant alveolar lining material lung lipids composition fatty acids
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520431050

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spelling	doaj-8d67d1f879f14fe1ba334ee358f3ea9c2021-04-24T05:55:27ZengElsevierJournal of Lipid Research0022-22751968-05-0193357365Morphological and lipid analysis of the alveolar lining material in dog lungT.N. Finley0S.A. Pratt1A.J. Ladman2L. Brewer3M.B. McKay4Departments of Medicine and Anatomy, The University of New Mexico School of Medicine, Albuquerque New Mexico 87106Departments of Medicine and Anatomy, The University of New Mexico School of Medicine, Albuquerque New Mexico 87106Departments of Medicine and Anatomy, The University of New Mexico School of Medicine, Albuquerque New Mexico 87106Departments of Medicine and Anatomy, The University of New Mexico School of Medicine, Albuquerque New Mexico 87106Departments of Medicine and Anatomy, The University of New Mexico School of Medicine, Albuquerque New Mexico 87106Endobronchial saline lavage was used to obtain acellular material and cells from the dog lung. The centrifuged lavage fluid yielded a sediment consisting of an upper white layer and a lower brown layer. The white layer was strongly surface-active. It consisted of a mixture of lipids and proteins; the composition of the lipid portion was the same in three dogs. The predominant lipids were phosphatidyl choline, cholesterol, and cholesteryl esters; 75-88% of the fatty acids in each phospholipid fraction were saturated.Electron microscopy showed a strong morphological resemblance between the white layer and alveolar lining material in situ.http://www.sciencedirect.com/science/article/pii/S0022227520431050endobronchial lavagepulmonary surfactantalveolar lining materiallung lipidscompositionfatty acids
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	T.N. Finley S.A. Pratt A.J. Ladman L. Brewer M.B. McKay
spellingShingle	T.N. Finley S.A. Pratt A.J. Ladman L. Brewer M.B. McKay Morphological and lipid analysis of the alveolar lining material in dog lung Journal of Lipid Research endobronchial lavage pulmonary surfactant alveolar lining material lung lipids composition fatty acids
author_facet	T.N. Finley S.A. Pratt A.J. Ladman L. Brewer M.B. McKay
author_sort	T.N. Finley
title	Morphological and lipid analysis of the alveolar lining material in dog lung
title_short	Morphological and lipid analysis of the alveolar lining material in dog lung
title_full	Morphological and lipid analysis of the alveolar lining material in dog lung
title_fullStr	Morphological and lipid analysis of the alveolar lining material in dog lung
title_full_unstemmed	Morphological and lipid analysis of the alveolar lining material in dog lung
title_sort	morphological and lipid analysis of the alveolar lining material in dog lung
publisher	Elsevier
series	Journal of Lipid Research
issn	0022-2275
publishDate	1968-05-01
description	Endobronchial saline lavage was used to obtain acellular material and cells from the dog lung. The centrifuged lavage fluid yielded a sediment consisting of an upper white layer and a lower brown layer. The white layer was strongly surface-active. It consisted of a mixture of lipids and proteins; the composition of the lipid portion was the same in three dogs. The predominant lipids were phosphatidyl choline, cholesterol, and cholesteryl esters; 75-88% of the fatty acids in each phospholipid fraction were saturated.Electron microscopy showed a strong morphological resemblance between the white layer and alveolar lining material in situ.
topic	endobronchial lavage pulmonary surfactant alveolar lining material lung lipids composition fatty acids
url	http://www.sciencedirect.com/science/article/pii/S0022227520431050
work_keys_str_mv	AT tnfinley morphologicalandlipidanalysisofthealveolarliningmaterialindoglung AT sapratt morphologicalandlipidanalysisofthealveolarliningmaterialindoglung AT ajladman morphologicalandlipidanalysisofthealveolarliningmaterialindoglung AT lbrewer morphologicalandlipidanalysisofthealveolarliningmaterialindoglung AT mbmckay morphologicalandlipidanalysisofthealveolarliningmaterialindoglung
_version_	1721511335902052352

Morphological and lipid analysis of the alveolar lining material in dog lung

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