The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nocicepti...

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Bibliographic Details
Main Authors: Thalita S Camargos, Frank Bosmans, Solange C Rego, Caroline B F Mourão, Elisabeth F Schwartz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4470819?pdf=render

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