The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nocicepti...

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Main Authors: Thalita S Camargos, Frank Bosmans, Solange C Rego, Caroline B F Mourão, Elisabeth F Schwartz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4470819?pdf=render
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spelling doaj-8d4adb1394644b749cdf7d4e8cd7054a2020-11-25T01:53:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012857810.1371/journal.pone.0128578The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.Thalita S CamargosFrank BosmansFrank BosmansSolange C RegoCaroline B F MourãoElisabeth F SchwartzWe identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function.http://europepmc.org/articles/PMC4470819?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Thalita S Camargos
Frank Bosmans
Frank Bosmans
Solange C Rego
Caroline B F Mourão
Elisabeth F Schwartz
spellingShingle Thalita S Camargos
Frank Bosmans
Frank Bosmans
Solange C Rego
Caroline B F Mourão
Elisabeth F Schwartz
The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
PLoS ONE
author_facet Thalita S Camargos
Frank Bosmans
Frank Bosmans
Solange C Rego
Caroline B F Mourão
Elisabeth F Schwartz
author_sort Thalita S Camargos
title The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
title_short The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
title_full The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
title_fullStr The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
title_full_unstemmed The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.
title_sort scorpion toxin tf2 from tityus fasciolatus promotes nav1.3 opening.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function.
url http://europepmc.org/articles/PMC4470819?pdf=render
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