Preoperative Alterations of Interleukin-6 levels During Surgical Removal of Impacted Lower Third Molar

• Main Authors: Harith D Qadawi, Atalla F. Rejab
• Format: Article
• Language: Arabic
• Published: University of Mosul, College of Dentistry 2014-04-01
• Series: Al-Rafidain Dental Journal
• Subjects: third molar surgery; cytokines; interleukin-6
• Online Access: https://rden.mosuljournals.com/pdf_89256_933475b5b0878bb62a060a8f943ac5e9.html
• ISSN: 1812-1217; 1998-0345

The aim of the study is to assess the blood levels of (interleukin-6) at different intervals of time after surgical removal of impacted lower third molars.. Materials and Methods: The study group comprised 26 patients with impacted lower third molars .All extractions were performed under local anaesthesia using the inferior alveolar nerve block together with vestibular infiltration. A buccal full thickness two sided mucoperiosteal flap was raised. Sterile low-speed straight hand pieces and sterile distilled water were used for ostectomy. After tooth removal the wound was closed with 3-0 black silk suture. Three blood samples were drawn from each patient; one before the operation, the second 2hr. post operation and the third 24hr. post operation. The blood samples were collected through venipunc-ture, serum separated and stored in at -20ºC. Analysis was performed using the Enzyme linked Im-munosourbant assay ( ELISA). Results: The level of IL-6, in this study, showed an increase following surgery, in comparison with the level before operation. This increase in the level of Interleukin-6 re-mained high until 24hr after operation. Conclusion: Interleukin-6 (IL-6) is higher after surgical extrac-tion of lower third molars and remained with high levels to 24hr. after operation